Polyhexamethylenebiguanide hydrochloride exposure and erythema multiforme in a physician.

نویسندگان

  • Jean-François Gehanno
  • Anne-Emmanuelle Priot
  • Xavier Balguerie
  • Jean-François Caillard
چکیده

A 52-year-old woman physician developed recurrent erythema multiforme. Occupational and environmental exposure assessment suggested a disinfectant containing polyhexamethylenebiguanide hydrochloride (PHMB), Phagosept. Elimination of the product was followed by disappearance of symptomatology. Literature search revealed cases of sensitization and anaphylaxis due to contact with PHMB, but to our knowledge, this is the first report on PHMB-induced erythema multiforme.

منابع مشابه

Use of steroids for erythema multiforme in children.

QUESTION I recently diagnosed an erythema multiforme rash in several patients, two of whom had the major variant, Stevens-Johnson syndrome. Should these patients be managed with corticosteroids? ANSWER In most cases, mild erythema multiforme is self-limited and resolves in 2 to 4 weeks. Stevens-Johnson syndrome is a serious disease that involves the mucous membranes and lasts up to 6 weeks. T...

متن کامل

Erythema multiforme.

Erythema multiforme is a skin condition considered to be a hypersensitivity reaction to infections or drugs. It consists of a polymorphous eruption of macules, papules, and characteristic "target" lesions that are symmetrically distributed with a propensity for the distal extremities. There is minimal mucosal involvement. Management involves treating the existing infectious agent or discontinui...

متن کامل

Anaphylaxis and hypersensitivity syndrome reactions in increasing severity following repeated exposure to tinidazole.

Anaphylaxis is a potentially life-threatening immunological reaction that results from the sudden release of mast-cell-de­ rived and basophil-derived mediators into the circulatory sys­ tem. Hypersensitivity syndrome reactions (HSR) include cu­ taneous eruptions like erythema multiforme and StevenJohnson syndrome, and are commonly induced by drugs. Ery­ thema multiforme (EM) is an acute, usuall...

متن کامل

Erythema multiforme in children: the steroid debate.

QUESTION In my office I occasionally see children who have rashes with "target lesions" and who are diagnosed with erythema multiforme (EM). When should these children receive steroids, and when should the illness be allowed to follow its natural course without steroid treatment? ANSWER Erythema multiforme is relatively common in children. Current recommendations suggest not to treat EM minor...

متن کامل

Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study.

BACKGROUND It was proposed that Stevens-Johnson syndrome and toxic epidermal necrolysis differed from erythema multiforme majus by the pattern and localization of skin lesions. OBJECTIVE To evaluate the validity of this clinical separation. DESIGN Case-control study. SETTINGS Active survey from 1989 to 1995 of 1800 hospital departments in Europe. PATIENTS A total of 552 patients and 172...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

متن کامل
عنوان ژورنال:
  • International journal of occupational medicine and environmental health

دوره 19 1  شماره 

صفحات  -

تاریخ انتشار 2006